Discover what we do!
Technical portfolio
In our lab, we make use of innovative techniques that help us unravel how metabolic and inflammatory pathways in immune and glial cells direct inflammation- and remyelination processes and how these pathways are modulated by therapeutic compounds.
Animal models
The EAE and cuprizone model, and gene deficient mice enable us to evaluate repair and inflammation processes in vivo.
Inflammatory and metabolic cell state
Analysis of the metabolic and inflammatory cellular phenotype by eg multicolor flowcytometry, cytokine arrays, RNAseq, Seahorse, lipid uptake and efflux
Organotypic cerebellar brain slice model
This intigrated ex vivo technique allows the study of remyelination processes in a dish.
Multi-omics
Combined (spatial) lipidomics, transcriptomics and proteomics in collab. with Lipometrix and LISCO of KULeuven
In vitro primary cell cultures
We use primary macrophages, microglia, T cells, and oligodendrocyte precursor cells to study cell-specific mechanisms.
Imaging
Live cell imaging, airyscan superresolution confocal microscopy, 3D rendering of de- and remyelination, inflammatory and metabolic processes
No research without funding!
We are supported by the following funding agencies.
